2. Bill Murray

Murray once joked to David Letterman that his pockmarked skin must be caused by someone poisoning him.

The actor got his start on Saturday Night Live, where he was a cast member for three years.

His looks took a backseat to his comedic chops on the famous sketch show and helped make Murray famous.

While he’s not a classically handsome leading man, he is a fan favorite, starring in hits like “Ghostbusters,” “Stripes,” and “Groundhog Day.”

As he has aged, Murray has found a new niche in films like “The Royal Tenenbaums,” “The Life Aquatic” with Steve Zissou, and “Moonrise Kingdom.”

Murray has earned numerous awards and nominations. His most recent nomination was for Best Actor in a Comedy or Musical for the film “Hyde Park on Hudson” at the 2013 Golden Globe Awards.

Perhaps his most acclaimed role to date has been in “Lost in Translation.” This film earned him a nomination for Best Actor at the 2004 Academy Awards, and a win in the same category at the Golden Globes.

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Murray’s great success in Hollywood has come despite the fact that he has neither a manager nor an agent, but prefers to handle all aspects of his career by himself.